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Your location: Home > Related Articles > Scientists use 3D printing technology to create a complete model of glioblastoma

Scientists use 3D printing technology to create a complete model of glioblastoma

Author:QINSUN Released in:2024-01 Click:82

At present, the commonly used model for tumor research is tumor cells grown in 2D culture dishes, but this model lacks the interaction between tumors and stroma, and cannot simulate the complex biological environment of tumor growth well. This is also the main reason why many anti-tumor drugs have shown good effects in the laboratory stage, but their actual effects are not satisfactory in clinical trials. To this end, a team of Israeli scientists used 3D printing technology to create a model that can simulate various biological features of neuroblastoma. The study was published in the journal Science Advances and titled: Microengineered Perfusable 3D bioprinted glioblastoma model for in vivo microscopy of tumor microenvironment.

Scientists have constructed a tumor microenvironment using fibrin glioblastoma bioink composed of glioblastoma cells, astrocytes, and microglia, and created perfusable blood vessels using bioink containing peribrain cells and endothelial cells. Researchers have observed that this 3D bioprinting model can simulate the cellular heterogeneity, intercellular interactions, and spatial tomography features of glioblastoma, and can reproduce various in vivo features of glioblastoma, including growth dynamics, invasive ability, therapeutic response, and genetic features.

Researchers believe that this 3D bioprinting model can better simulate clinical scenarios of various types of cancer and may become a reliable technical platform for preclinical research and drug screening.